Prostaglandins and Inflammation
نویسندگان
چکیده
منابع مشابه
Prostaglandins and inflammation.
Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain homeostatic functions and mediate pathogenic mechanisms, including the inflammatory response. They are generated from arachidonate by the action of cyclooxygenase isoenzymes, and their biosynthesis is blocked by nonsteroidal antiinflammatory drugs, including those selective for inhibition of cyclooxygenase-2. De...
متن کاملProstaglandins and inflammation: the cyclooxygenase controversy.
Prostaglandins (PGs) are arachidonic acid metabolites produced by the action of the enzyme cyclooxygenase (COX). Although PGs are important mediators of inflammation in various diseases, they also are key factors in the physiological regulation of gastrointestinal and renal homeostasis. The finding that two distinct COX isoforms are responsible for PG synthesis has provided basis to the opposit...
متن کاملThe effect of intravitreal and topical prostaglandins on intraocular inflammation.
We investigated the effects of prostaglandins (PG) E2, PGD2, PGI2, and its metabolites 6-keto-PGE1 and 6-keto-PGF1 alpha, and U46619 (stable analogue of the PG endoperoxide, PGH2) administered either intravitreally or topically on intraocular pressure (IOP), pupil diameter, aqueous protein, and the entry of polymorphonuclear cells (PMNs) in the aqueous. PGE2, 6-keto-PGE1, U46619, and PGI2 incre...
متن کاملProstaglandins mediate the fetal pulmonary response to intrauterine inflammation
Westover AJ, Hooper SB, Wallace MJ, Moss TJM. Prostaglandins mediate the fetal pulmonary response to intrauterine inflammation. Am J Physiol Lung Cell Mol Physiol 302: L664–L678, 2012. First published January 27, 2012; doi:10.1152/ajplung.00297.2011.— Intra-amniotic (IA) lipopolysaccharide (LPS) induces intrauterine and fetal lung inflammation and increases lung surfactant and compliance in pre...
متن کاملProstaglandins
Knowledge of the structure and synthesis of antibodies (immunoglobulins) has developed to a remarkable degree in the last decade. Distinct classes of immunoglobulin (yG, yM, -yA, yD, yE, and their subgroups) have been identified and shown to consist of fixed numbers of light and heavy polypeptide chains organized in pairs. Each polypeptide has a segment of variable amino acid sequence; the spec...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2011
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.110.207449